• Project Title: How to Increase Anti-Angiogenesis Through Increased Isoflavone Synthase Expression

  • BASIS Advisor: Dr. Murthy

  • Internship Location: Intel

  • Onsite Mentor: Mr. Xing Su

Cancer has prevailed for centuries, and yet we are nowhere close to finding a cure. However, we have developed a wide variety of treatments to attack or treat cancer. One method of treatment is anti-angiogenesis. Angiogenesis is the process of blood vessel formation. By preventing angiogenesis, cancer cells are essentially starved to death as they have no way of gaining nutrients. There has been research done on anti-angiogenic properties of foods like soy; for mung beans, research has identified that isoflavones are a key part of the anti-cancer properties. Conducting my research at Intel, I aim to write a research paper that compares isoflavone synthase 2 (which are involved in making isoflavones, proteins that can help prevent angiogenesis or blood vessel formation) mRNA expression levels at different times and different parts of plants during germination in mung beans. I will accomplish this by designing a primer and running qPCR (Quantitative Polymerase Chain Reaction) which will allow me to quantitate mRNA levels and thus indirectly quantitate amount of isoflavones. Currently, there are many organizations that are focused on making purified extracts, and I believe my research can help with effectively extracting isoflavones. This could also help with people who are growing mung beans in identifying the most beneficial time to harvest.